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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1B3
All Species:
32.73
Human Site:
T390
Identified Species:
65.45
UniProt:
Q02153
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02153
NP_000848.1
619
70514
T390
L
E
D
E
K
K
K
T
D
T
L
L
Y
S
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O54865
620
70579
T390
L
E
D
E
K
K
K
T
D
T
L
L
Y
S
V
Rat
Rattus norvegicus
P20595
619
70438
T390
L
E
D
E
K
K
K
T
D
T
L
L
Y
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510819
683
77917
T413
L
E
D
E
K
K
K
T
D
T
L
L
Y
S
V
Chicken
Gallus gallus
XP_420376
698
78758
T472
L
E
D
E
K
K
K
T
D
T
L
L
Y
S
V
Frog
Xenopus laevis
NP_001085192
609
69543
K388
R
A
L
E
D
E
K
K
K
T
D
T
L
L
Y
Zebra Danio
Brachydanio rerio
XP_001920263
608
69179
D385
H
T
L
R
A
L
E
D
E
K
K
K
T
D
R
Tiger Blowfish
Takifugu rubipres
NP_001027728
617
70218
T390
L
E
D
E
K
K
K
T
D
R
L
L
Y
S
V
Fruit Fly
Dros. melanogaster
Q8INF0
947
105028
R387
L
L
D
E
E
M
R
R
T
D
E
L
L
Y
Q
Honey Bee
Apis mellifera
NP_001011632
603
68286
T380
L
D
G
E
K
Q
K
T
D
R
L
L
Y
S
V
Nematode Worm
Caenorhab. elegans
Q6DNF4
675
76632
T419
L
E
V
E
K
G
K
T
D
A
L
L
R
E
M
Sea Urchin
Strong. purpuratus
P16065
1125
126238
T883
L
Q
K
E
K
T
K
T
E
Q
L
L
H
R
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
N.A.
N.A.
98.7
98.8
N.A.
88.2
85.8
93.6
88
87.4
24.2
63.8
32.2
20.1
Protein Similarity:
100
N.A.
N.A.
N.A.
N.A.
99.3
99.5
N.A.
89.5
86.9
96.2
93.6
94
38.6
77.7
52.4
32.5
P-Site Identity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
100
100
20
0
93.3
26.6
73.3
60
46.6
P-Site Similarity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
100
100
26.6
13.3
93.3
40
86.6
66.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
9
0
0
0
0
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
59
0
9
0
0
9
67
9
9
0
0
9
0
% D
% Glu:
0
59
0
92
9
9
9
0
17
0
9
0
0
9
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
0
0
9
0
0
0
0
0
0
0
0
0
% G
% His:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
9
0
75
50
84
9
9
9
9
9
0
0
0
% K
% Leu:
84
9
17
0
0
9
0
0
0
0
75
84
17
9
0
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
17
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
9
0
0
0
9
0
0
0
9
0
0
0
0
9
% Q
% Arg:
9
0
0
9
0
0
9
9
0
17
0
0
9
9
9
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
59
0
% S
% Thr:
0
9
0
0
0
9
0
75
9
50
0
9
9
0
0
% T
% Val:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
59
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
59
9
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _